Rational Fragment-design Method Based on a Thermodynamic Analysis
نویسندگان
چکیده
منابع مشابه
Thermodynamic analysis in fragment-based drug discovery
Thermodynamic analysis provides access to the determinants of binding affinity, enthalpy and entropy. In fragment-based drug discovery (FBDD), thermodynamic analysis provides a powerful tool to discriminate fragments based on their potential for successful optimization. The thermodynamic data generated by FBDD studies can in turn be used to better understand the forces that drive biomolecular i...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2009
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.129.1311